Christy Bryant

De novo design of a reversible phosphorylation-dependent switch for membrane targeting

De novo design of a reversible phosphorylation-dependent switch for membrane targeting

Modules that switch protein-protein interactions on and off are important to develop artificial biology; for instance, to assemble orthogonal signaling pathways, to manage synthetic protein constructions dynamically, and for protein localization in cells or protocells. In nature, the E. coli MinCDE system {couples} nucleotide-dependent switching of MinD dimerization to membrane targeting to set off spatiotemporal sample formation. Here …

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Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies

Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies

The liver as the largest organ in the human physique consists of a posh macroscopic and microscopic structure that helps its indispensable perform to take care of physiological homeostasis. Optical imaging of the human liver is especially difficult as a result of of the have to cowl size scales throughout 7 orders of magnitude (from …

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Asymmetry, division of labour and the evolution of ageing in multicellular organisms

Asymmetry, division of labour and the evolution of ageing in multicellular organisms

Between the 1930s and 1960s, evolutionary geneticists labored out the fundamental rules of why organisms age. Despite a lot progress in the evolutionary biology of ageing since that point, nevertheless, many puzzles stay. The maybe most basic of these is the query of which organisms ought to exhibit senescence and which shouldn’t (or which ought to age …

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Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis

Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis

Gliomas are the most typical central nervous system malignancies and current with vital morbidity and mortality. Treatment modalities are presently restricted to surgical resection, chemotherapy and radiotherapy. Increases in survival charge over the earlier a long time are negligible, additional pinpointing an unmet scientific want in this area. There is a continuous battle with the event …

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Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering

Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering

The purposes of hydrogels in biomedical discipline has been since a number of many years. Discoveries in biology and chemistry render this platform endowed with a lot engineering potentials and rising repeatedly. Novel approaches in establishing these supplies have led to the manufacturing of complicated hybrid hydrogels methods that may incorporate each pure and artificial polymers and different practical …

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MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer.

MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer.

Cancer cells have an elevated demand for power sources to help accelerated charges of development. When vitamins change into limiting, most cancers cells could change to nonconventional power sources which might be mobilized via nutrient scavenging pathways involving autophagy and the lysosome. Thus, a number of cancers are extremely reliant on constitutive activation of these …

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Spastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function.

Spastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function.

The hereditary spastic paraplegias (HSPs) are genetic motor neuron ailments characterised by progressive degeneration of corticospinal tract axons. Mutations in SPAST, encoding the microtubule-severing ATPase spastin, are the most typical causes of HSP. The broad SPAST mutational spectrum signifies a haploinsufficiency pathogenic mechanism generally. Most missense mutations cluster within the ATPase area, the place they …

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MiT family translocation renal cell carcinoma after malignant infantile osteopetrosis in childhood: a case report.

MiT family translocation renal cell carcinoma after malignant infantile osteopetrosis in childhood: a case report.

Malignant infantile osteopetrosis (MIOP) is a uncommon inherited bone metabolism dysfunction characterised by elevated bone mineral density (BMD) and irregular hematopoiesis. Hematopoietic stem cell transplantation (HSCT) is at present the one healing remedy for MIOP. However, a greater danger of secondary malignancy happens in kids beforehand uncovered to cytotoxic medicine. Here we report a uncommon …

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Protocols available upon request

Dop you need an Msds? info@icsb-2005.org Assay Kits Cell Culture Equipment Mutagenesis Infectious Disease Antibodies Vector Construction RNA CRISPR Products Stem Cell Culture and reagents High Throughput Screening Apoptosis Antibodies Antibodies Buffy Coat Concentrate Chemicals and Reagents Nucleic Acid Stains Proteomic and biochemistry Services Sequencing Biomolecules Microscopes and Mobile Imaging Systems Liquid Handling Workstations Laboratory …

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