De novo design of a reversible phosphorylation-dependent switch for membrane targeting

De novo design of a reversible phosphorylation-dependent switch for membrane targeting

Modules that switch protein-protein interactions on and off are important to develop artificial¬†biology; for instance, to assemble orthogonal signaling pathways, to manage synthetic protein constructions dynamically, and for protein localization in cells or protocells. In nature, the E. coli MinCDE¬†system¬†{couples} nucleotide-dependent switching of MinD dimerization to membrane targeting to set off spatiotemporal sample formation. Here …

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