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De novo design of a reversible phosphorylation-dependent switch for membrane targeting

De novo design of a reversible phosphorylation-dependent switch for membrane targeting

Modules that switch protein-protein interactions on and off are important to develop artificial biology; for instance, to assemble orthogonal signaling pathways, to manage synthetic protein constructions dynamically, and for protein localization in cells or protocells. In nature, the E. coli MinCDE system {couples} nucleotide-dependent switching of MinD dimerization to membrane targeting to set off spatiotemporal sample formation. Here …

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Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies

Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies

The liver as the largest organ in the human physique consists of a posh macroscopic and microscopic structure that helps its indispensable perform to take care of physiological homeostasis. Optical imaging of the human liver is especially difficult as a result of of the have to cowl size scales throughout 7 orders of magnitude (from …

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Asymmetry, division of labour and the evolution of ageing in multicellular organisms

Asymmetry, division of labour and the evolution of ageing in multicellular organisms

Between the 1930s and 1960s, evolutionary geneticists labored out the fundamental rules of why organisms age. Despite a lot progress in the evolutionary biology of ageing since that point, nevertheless, many puzzles stay. The maybe most basic of these is the query of which organisms ought to exhibit senescence and which shouldn’t (or which ought to age …

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Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis

Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis

Gliomas are the most typical central nervous system malignancies and current with vital morbidity and mortality. Treatment modalities are presently restricted to surgical resection, chemotherapy and radiotherapy. Increases in survival charge over the earlier a long time are negligible, additional pinpointing an unmet scientific want in this area. There is a continuous battle with the event …

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Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering

Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering

The purposes of hydrogels in biomedical discipline has been since a number of many years. Discoveries in biology and chemistry render this platform endowed with a lot engineering potentials and rising repeatedly. Novel approaches in establishing these supplies have led to the manufacturing of complicated hybrid hydrogels methods that may incorporate each pure and artificial polymers and different practical …

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Protocols available upon request

Dop you need an Msds? info@icsb-2005.org Assay Kits Cell Culture Equipment Mutagenesis Infectious Disease Antibodies Vector Construction RNA CRISPR Products Stem Cell Culture and reagents High Throughput Screening Apoptosis Antibodies Antibodies Buffy Coat Concentrate Chemicals and Reagents Nucleic Acid Stains Proteomic and biochemistry Services Sequencing Biomolecules Microscopes and Mobile Imaging Systems Liquid Handling Workstations Laboratory …

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Addgene kits

Fluorescent Proteins LIC TAL Effector Meeting Kit – Hornung Yeast GoldenBraid Cloning System and Toolkit – Bernat Hsa21 Gene Expression Set – Reeves MultiSite Gateway Kit – Planas & Santalucia FREQ-Seq Kit for constructing barcoded, locus-specific libraries (Illumina compatible) – Marx Zinc Fingers STAR TALE Meeting Kit – Pollard Zebrafish Tol2 Gateway-compatible Kit for Neurodegenerative …

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