Recent Advances and Current Trends in Nucleotide Second Messenger Signaling in Bacteria.

The “International Symposium on Nucleotide Second Messenger Signaling in Bacteria” (September 30-October 3, 2018, Berlin), which was organized within the framework of DFG Priority Programme 1879 (www.spp1879.de), brought together 125 participants from 20 countries to discuss recent progress and future trends in this field.

Even 50 years after its discovery, (p)ppGpp is venturing into exciting new fields, especially in gram-positive bacteria. After triggering the current renaissance in bacterial second messenger research, c-di-GMP is becoming ever more global with abounding new molecular mechanisms of action and physiological functions.

The more recently discovered c-di-AMP is rapidly catching up and has now been found even in archaea, with its function in osmotic homeostasis being conserved across kingdom boundaries. Small modules associated with mobile genetic elements, which make and react to numerous novel mixed cyclic dinucleotides, seem to roam around rather freely in the bacterial world.

Finally, many novel and old nucleotide molecules are still lurking around in search of a function. Across many talks it became apparent that (p)ppGpp, c-di-GMP and GTP/ATP can share and compete for binding sites (e.g., the Walker A motif in GTP/ATPases) with intriguing regulatory consequences, thus contributing to the emergent trend of systemwide networks that interconnect diverse signaling nucleotides.

TOK-001

A8623-10 10 mg
EUR 128
Description: CYP17 inhibitor and androgen receptor (AR) antagonist

TOK-001

A8623-5.1 10 mM (in 1mL DMSO)
EUR 80
Description: CYP17 inhibitor and androgen receptor (AR) antagonist

TOK-001

A8623-50 50 mg
EUR 376
Description: CYP17 inhibitor and androgen receptor (AR) antagonist

ICG 001

A8217-10 10 mg
EUR 87
Description: Wnt/β-catenin pathway inhibitor

ICG 001

A8217-100 100 mg
EUR 465
Description: Wnt/β-catenin pathway inhibitor

ICG 001

A8217-25 25 mg
EUR 203
Description: Wnt/β-catenin pathway inhibitor

ICG 001

A8217-5 5 mg
EUR 53
Description: Wnt/β-catenin pathway inhibitor

ICG 001

A8217-5.1 10 mM (in 1mL DMSO)
EUR 88
Description: Wnt/β-catenin pathway inhibitor

ICG 001

A8217-S Evaluation Sample
EUR 22
Description: Wnt/β-catenin pathway inhibitor

RRX-001

205870 10.0mg
EUR 450

ICG-001

2275-25 each
EUR 692.4

ICG-001

2275-5 each
EUR 222

ICG 001

27752-1 10 mg
EUR 175
Description: CG001 is a small molecule inhibitor that targets Wnt/β-catenin pathway. It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 µM. It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.

ICG 001

27752-2 100 mg
EUR 710
Description: CG001 is a small molecule inhibitor that targets Wnt/β-catenin pathway. It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 µM. It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.

ICG 001

27752-3 25 mg
EUR 330
Description: CG001 is a small molecule inhibitor that targets Wnt/β-catenin pathway. It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 µM. It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.

ATX-001

465713 5.0mg
EUR 350

ICG-001

E1KS2662 5mg1​ PHYSICAL AND CHEMICAL PROPERTIES
EUR 362.4

ABL-001

B1949-1 each
EUR 183.6

ABL-001

B1949-5 each
EUR 548.4

KL 001

B5684-10 10 mg
EUR 226
Description: cryptochrome protein (CRY) stabilizer

KL 001

B5684-25 25 mg
EUR 351.6

KL 001

B5684-5 5 mg
EUR 142.8

KL 001

B5684-50 50mg
EUR 926
Description: cryptochrome protein (CRY) stabilizer

EPI-001

B6041-10 10 mg
EUR 56
Description: AR antagonist

EPI-001

B6041-200 200 mg
EUR 376
Description: AR antagonist

EPI-001

B6041-50 50 mg
EUR 168
Description: AR antagonist

SDB-001

571060 1.0mg
EUR 250

AT-001

573537 5.0mg
EUR 250

EPI-001

555572 10.0mg
EUR 250

ICG-001

HY-14428 100mg
EUR 968.4

RRx-001

HY-16438 100mg
EUR 2208

ICG-001

SIH-387-25MG 25 mg
EUR 514
Description: β-catenin inhibitor

ICG-001

SIH-387-5MG 5 mg
EUR 145
Description: β-catenin inhibitor

TBAP-001

T9693-10mg 10mg Ask for price
Description: TBAP-001

TBAP-001

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Description: TBAP-001

TBAP-001

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Description: TBAP-001

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Description: TBAP-001

TBAP-001

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Description: TBAP-001

RP-001

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RP-001

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Description: RP-001

RP-001

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Description: RP-001

RP-001

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RP-001

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LJ-001

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LJ-001

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LJ-001

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LIT-001

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LIT-001

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LIT-001

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NPD-001

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Description: NPD-001

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Description: AVX-001

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ALK-001

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PCLX-001

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Description: PCLX-001

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Description: PCLX-001

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Description: PCLX-001

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Description: PCLX-001

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Description: PCLX-001

ICG-001

abx076792-100l 100 µl
EUR 131.25

ICG-001

abx076792-1ml 1 ml Ask for price

ICG-001

abx076792-200l 200 µl
EUR 350

KL-001

abx282309-100g 100 µg Ask for price

KL-001

abx282309-20g 20 µg
EUR 131.25

KL-001

abx282309-50g 50 µg
EUR 287.5

(+/-)-((exo, RS), RS) Biperiden Hydrochloride

B397945 100mg
EUR 127
Description: 475563-22-5

(+/-)-((endo, RS), RS) Biperiden Hydrochloride

B397948 2.5mg
EUR 304

RP-001 hydrochloride

574391 5.0mg
EUR 305

RP 001 hydrochloride

B7634-10 10 mg
EUR 288
Description: S1P1 receptor agonist

RP 001 hydrochloride

B7634-25 25 mg
EUR 618
Description: S1P1 receptor agonist

RP 001 hydrochloride

B7634-5 5 mg
EUR 186
Description: S1P1 receptor agonist

LIT-001 TFA

555325 5.0mg
EUR 150

RP-001 hydrochloride

T12780L-10mg 10mg Ask for price
Description: RP-001 hydrochloride

RP-001 hydrochloride

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Description: RP-001 hydrochloride

RP-001 hydrochloride

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RO320-2947/001

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Description: RO320-2947/001

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T34370-5mg 5mg Ask for price
Description: RO320-2947/001

RS-09

574392 1.0mg
EUR 315

RS-5

ABC-TC0996 1 vial Ask for price
Description: Established in 2003 from the untreated malignant mesothelioma of the pleura of a 78-year-old man with asbestos cancer.

RS-1

406955 100.0mg
EUR 650

RS-504393

B2406-25 each
EUR 836.4

RS-504393

B2406-5 each
EUR 261.6

(RS)-APICA

B6584-10 10 mg
EUR 211
Description: group II metabotropic glutamate receptor antagonist

(RS)-APICA

B6584-50 50 mg
EUR 867
Description: group II metabotropic glutamate receptor antagonist

(RS)-PPG

B6640-25 25 mg
EUR 475
Description: group III metabotropic glutamate receptor agonist

(RS)-PPG

B6640-5 5 mg
EUR 126
Description: group III metabotropic glutamate receptor agonist

RS-1

B1118-25 each
EUR 652.8

RS-1

B1118-5 each
EUR 210

(RS)-(±)-Sulpiride

B6492-100 100 mg
EUR 40
Description: D2-like dopamine receptor antagonist

(RS)-(±)-Sulpiride

B6492-5.1 10 mM (in 1mL DMSO)
EUR 180

(RS)-AMPA

B6213-10 10 mg
EUR 169
Description: AMPA agonist

(RS)-AMPA

B6213-50 50 mg
EUR 760
Description: AMPA agonist

(RS)-CPP

B6214-10 10 mg
EUR 237
Description: NMDA antagonist

(RS)-CPP

B6214-50 50 mg
EUR 1000
Description: NMDA antagonist

(RS)-MCPG

B6265-10 10 mg
EUR 126
Description: mGluR antagonist

(RS)-MCPG

B6265-100 100 mg
EUR 900
Description: mGluR antagonist

(RS)-MCPG

B6265-25 25 mg
EUR 278
Description: mGluR antagonist

(RS)-MCPG

B6265-5 5 mg
EUR 91
Description: mGluR antagonist

(RS)-MCPG

B6265-5.1 10 mM (in 1mL DMSO)
EUR 250.8

(RS)-MCPG

B6265-50 50 mg
EUR 490
Description: mGluR antagonist

RS-1

C3357-10 10 mg
EUR 61
Description: RAD51 activator

RS-1

C3357-25 25 mg
EUR 115
Description: RAD51 activator

RS-1

C3357-50 50 mg
EUR 203
Description: RAD51 activator

RS-504393

522415 1.0mg
EUR 220

RS 127445

A3778-10 10 mg
EUR 64
Description: 5-HT2B receptor antagonist,high affinity

RS 127445

A3778-5 5 mg
EUR 40
Description: 5-HT2B receptor antagonist,high affinity

RS 127445

A3778-5.1 10 mM (in 1mL DMSO)
EUR 44
Description: 5-HT2B receptor antagonist,high affinity

RS 127445

A3778-50 50 mg
EUR 256
Description: 5-HT2B receptor antagonist,high affinity

RS 504393

A3779-10 10 mg
EUR 218
Description: CCR2 chemokine receptor antagonist

RS 504393

A3779-25 25 mg
EUR 476
Description: CCR2 chemokine receptor antagonist

RS 504393

A3779-5 5 mg
EUR 131
Description: CCR2 chemokine receptor antagonist

RS 504393

A3779-50 50mg
EUR 834
Description: CCR2 chemokine receptor antagonist

(RS)-MCPG

555671 100.0mg
EUR 950

RS-246204

HY-112484 10mM/1mL
EUR 590.4

RS 8359

HY-14260 5mg
EUR 1383.6

(RS)-Carbocisteine

HY-D0205 100mg
EUR 142.8

RS 504393

HY-15418 10mg
EUR 315.6

RS 127445

HY-15419 10mM/1mL
EUR 151.2

RS-1

HY-19793 10mM/1mL
EUR 154.8

(RS)-MCPG

HY-100371 100mg
EUR 1135.2

(RS)-Butyryltimolol

HY-102032A 100mg
EUR 1230

RS-601

HY-U00072 10mg
EUR 9993.6

(RS)-MCPG

M264743 100mg
EUR 3000
Description: 146669-29-6

RS 102895

R700935 250mg
EUR 1800
Description: 300815-41-2

RS-127445

R700953 100mg
EUR 1200
Description: 199864-87-4

RS 504393

R701020 1g
EUR 4500
Description: 300816-15-3

RS-25344

T9239-10mg 10mg Ask for price
Description: RS-25344

RS-25344

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Description: RS-25344

RS-25344

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Description: RS-25344

RS-25344

T9239-5mg 5mg Ask for price
Description: RS-25344

LPS-RS

tlrl-rslps 5 mg
EUR 219.45

RS-601

T12771-10mg 10mg Ask for price
Description: RS-601

RS-601

T12771-1g 1g Ask for price
Description: RS-601

RS-601

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Description: RS-601

RS-601

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Description: RS-601

RS-601

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Description: RS-601

(RS)-PPG

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Description: (RS)-PPG

(RS)-PPG

T12772-1g 1g Ask for price
Description: (RS)-PPG

Overall, this inspiring conference made it clear that second messenger signaling is currently one of the most dynamic and exciting areas in microbial molecular biology and physiology, with major impacts ranging from microbial systemsbiology and ecology to infection biology.

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